Leukotrienes A

《英文msh詞典》Leukotrienes A
[入口詞] Leukotrienes A
[主題詞] Leukotriene A4
[英文釋義] (2S-(2 alpha,3 beta(1E,3E,5Z,8Z)))-3-(1,3,5,8-Tetradecatetraenyl)oxiranebutanoic acid. An unstable allylic epoxide,formed from the immediate precursor 5-HPETE via the stereospecific removal of a proton at C-10 and dehydration. Its biological actions are determined primarily by its metabolites,i.e.,LEUKOTRIENE B4 and cysteinyl-leukotrienes. Alternatively,leukotriene A4 is converted into LEUKOTRIENE C4 by glutathione-S-transferase or into 5,6-di-HETE by the epoxide-hydrolase. (From Dictionary of Prostaglandins and Related Compounds,1990)